SEOLREIM · JOURNAL
Rejuran HB Plus versus Rejuran Healer: comparing pain, ingredients and quotations
Full translation of the Korean article. Translation checked for completeness, numerical consistency and medical meaning; separate medical review of this translation is pending. Translation updated: 2026-10-28.
Rejuran HB Plus and Rejuran Healer should not be compared as though they were the same product under one name. Published product information describes HB Plus as a formulation adding HA and lidocaine to PN, while Healer is PN-focused. During consultation, check not only pain expectations but also treatment goals, exact product names, amount per syringe, actual number used and the total quotation including anesthesia, aftercare and taxes. The name HB alone cannot guarantee stronger regeneration or painless treatment.
How to read HB and Healer quotations without treating their cc as equivalent
First ask for the full product name, Rejuran HB Plus or Rejuran Healer, on the quotation, and check the unopened packaging and quantity used. Composition and package units may differ between products, so do not assume an equivalent treatment amount from “1 syringe” or “2cc” alone. Pain depends not only on lidocaine content but also on injection site, depth, speed, number of injections, anesthesia method and individual sensitivity. An expectation that HB Plus may hurt less differs from a claim that it is painless for everyone. Whether the goal is dryness and fine lines or overall skin texture should also be assessed during examination, separately from product selection.
| Item | Questions to ask | Misinterpretations |
|---|---|---|
| Exact product | Is it HB Plus or Healer? | Assuming the same formulation because both share the Rejuran name |
| Components | Does it contain HA and lidocaine in addition to PN? | Declaring superiority based on a single ingredient |
| Quantity | What is the amount per syringe, and how many are actually opened? | Directly converting cc or syringes between different products |
| Pain management | What are the topical anesthesia, injection method and stopping criteria? | Expecting painless treatment because lidocaine is included |
| Total quote | Are product, anesthesia, areas, aftercare and taxes included? | Comparing only the advertised price and overlooking additional costs |
Definitions and how the treatments work
The Rejuran product family involves injecting polynucleotides (PN) into the skin. Official and regulatory materials for HB Plus describe a combination of PN, HA and lidocaine. HA adds hydration-related physical properties and lidocaine is a local anesthetic, but this composition alone does not establish superiority over Healer for all skin concerns or longer-lasting effects. The exact Korean approval, instructions for use and the patient’s skin condition take priority.
Potential benefits and limitations
In suitable candidates, treatment may aim to improve appearance related to skin texture, fine lines and hydration. The degree and timing of changes vary, and complete results from a single travel visit or permanent maintenance cannot be guaranteed. Expectations of less pain do not mean greater effects; diagnosis and injection planning matter more than product selection.
Who can seek a consultation and how suitability is assessed
Adults concerned about fine lines, dryness or skin texture may seek consultation. Disclose allergy history including fish allergies, hypersensitivity to local anesthetics, active infection, dermatitis or herpes, pregnancy or breastfeeding, medications that increase bleeding risk, past keloids or nodules, and recent lasers, fillers or skin boosters. Do not stop medication on your own; the clinician checks the actual product ingredients and contraindications.
Procedure, recovery and scheduling
The physician checks skin condition and goals and explains the product, areas, quantity, injection method, anesthesia and monitoring plan before returning home. Small injection wheals, redness, tenderness, swelling and bruising may be visible for several days or longer, depending on the product and individual response. Before a photo session or important event, do not assume a fixed time for wheals to settle; discuss allowing sufficient time.
Side effects, contraindications and symptoms requiring medical attention
Infection, bleeding, bruising, hypersensitivity reactions, persistent swelling, nodules and rare vascular complications are possible. Worsening pain, heat, pus, fever, skin becoming pale or developing a netlike color pattern, and visual disturbances require immediate assessment. Do not apply product substitution ratios or pain scores seen online as an individual prescription.
Compare goals and actual usage rather than product names
| Category | Role and goals | What to check |
|---|---|---|
| Rejuran Healer | PN-focused goals for skin texture and fine lines | Exact product, quantity, anesthesia and injection areas |
| Rejuran HB Plus | A formulation adding HA and lidocaine to PN | Separate expectations of pain reduction from claims of superior efficacy |
| HA hydration injections | HA-based goals for hydration and radiance | Do not equate them with Rejuran HB based only on names or cc |
Questions and answers for a medical consultation
These consultation questions were compiled from the literature and do not represent a clinician interview or an individual prescription. Clinical review of the new article has not yet been completed.
Q. Does HB Plus always hurt less than Healer?
A. It contains lidocaine, but pain also depends on the area, injection method, anesthesia and individual sensitivity. Painless treatment cannot be guaranteed.
Q. If HB Plus costs more, are its effects greater?
A. Price and effects are not proportional. Compare composition, quantity, goals, total quotation and evidence separately.
Q. Can I make just one trip to Seoul?
A. What is possible in one visit and the repeat-treatment plan depend on skin condition and goals. Also discuss the feasibility of care after returning home.
Consultation with the SEOLREIM clinic director and signature programs
SEOLREIM Clinic states its principles of physician-led consultations and procedures, genuine products, accurate quantities and attentive care. Consultation starts by distinguishing skin condition and goals, then checking the products and devices actually available, approved indications, dose or energy plans, recovery and risks. For program names on the official menu, such as Shining and Royal Rejuran, confirm the actual products, quantities and components during consultation. Under SEOLREIM’s principles of physician-led consultations and procedures, genuine products, accurate quantities and attentive care, the opened products and plan are checked; HB Plus is not automatically recommended as an upgrade for every visitor.
Booking, languages, location and guidance for international visitors
Visitors comparing Rejuran Korea quotations at dermatology clinics in Gangnam or Seoul should send their desired areas, pain concerns, allergies, medications, previous injection history and return-home date in advance. Even if you found a clinic by searching for a dermatology clinic near Gangnam Station or in Korea, the website language does not guarantee actual consultation or interpretation in that language; check before booking. SEOLREIM Clinic is on the 11th floor of the Gangnam8258 Building, approximately 1 minute from exit 3 of Gangnam Station. Book through the website’s KakaoTalk consultation, Naver booking or telephone channels. International visitors comparing dermatology clinics in Gangnam, Seoul, near Gangnam Station or elsewhere in Korea should prepare information on medications, allergies, recent procedures and departure dates. When booking, state your preferred language, such as Japanese, Chinese, Arabic, Mongolian or Indonesian, and whether interpretation is needed, and confirm the actual scope and cost of support. Continuous consultation availability in each language and same-day procedures cannot be guaranteed. During consultation, also agree on how to contact the clinic about adverse reactions after returning home and the follow-up schedule.
Evidence sources and related articles
Official Rejuran product instructions: https://rejuran.co.kr/manual/RJR.pdf ; PharmaResearch report on HB Plus composition and approval: https://www.koreabiomed.com/news/articleView.html?idxno=10989 ; SEOLREIM official menu and location: https://www.sulskin.co.kr/pages/en/product-30 . Observations of public questions were used only to identify interest in product differences, pain and price comparisons, not as evidence of medical efficacy. Evidence and official information checked: 2026-10-21.
Related article: What is Rejuran? A complete guide to salmon DNA skin booster effects, types and treatment intervals (as of 2026) https://www.sulskin.co.kr/pages/en/product-127 / Anesthetic cream safety for Rejuran and skin boosters: reducing pain and risks of excessive application https://www.sulskin.co.kr/pages/en/product-330 / Rejuran 2cc and Juvelook 2cc: are they the same amount? Comparing skin-booster quotes for overseas clients https://www.sulskin.co.kr/pages/en/product-354
Authorship, review and dates
Written by: SEOLREIM Content Editor / Medical professional review: completed / Review confirmed: 2026-10-23 / Published: 2026-10-21 / Updated: 2026-10-27. General medical information; not a substitute for individual diagnosis or a treatment prescription.
SEOLREIM · GANGNAM, SEOUL
Discuss Skin Treatments in Seoul with Seolreim Clinic.
Seolreim Clinic provides doctor-led consultation and treatment, following its principles of genuine products, accurate quantities and attentive care.
Tell us your treatment interests, skin concerns, dates in Korea and preferred consultation language. Confirm treatment suitability, recovery plans and language support before booking.